for the Alzheimer's Disease Neuroimaging Initiative
Abstract:The ability to recognize one's own limitations and decide whether to solve a problem or delegate is fundamental for reliable intelligent systems. Yet we show that modern large language models systematically lack this ability: across diverse model families and scales, they overestimate their competence and attempt queries they cannot solve. We refer to this ability as Capability Self-Assessment (CSA) and formulate it as a policy-learning problem, aiming to improve self-assessment while preserving the model's original capabilities. Our results show that reinforcement learning teaches CSA effectively, significantly outperforming supervised fine-tuning while preserving original capabilities. In contrast, supervised fine-tuning severely degrades the capabilities the model is meant to assess. Moreover, learned self-assessment behavior generalizes well out of distribution, suggesting that CSA is a transferable model trait. Finally, CSA is practically useful: it improves local-cloud decision making at inference time and provides a signal for targeted data selection during training.
Abstract:As policy catches up with the capabilities of generative AI, watermarking is central to content provenance efforts. Inference-time watermarks for autoregressive models are unfit for continuous modalities due to discretization inconsistencies. Existing methods overcome this by finetuning the modality tokenizers, nullifying the watermark's training-free advantage. In this work, motivated by the vocabulary redundancy of discretization, we propose an elegant solution for powerful and robust watermarking of synthetic audio. We theoretically analyze the impact of token errors on watermark detection, and effectively mitigate them using a reduced vocabulary obtained via community detection. Thorough experiments showcase that our gradient-free method can boost detectability by several orders of magnitude, while also achieving built-in robustness to audio modifications. Broadly, we discover a new state-of-the-art for token-level watermarks in multimedia, which simply arises from the nature of discrete representation learning.
Abstract:Many safety-critical control problems are modeled as risk-sensitive partially observable Markov decision processes, where the controller must make decisions from incomplete observations while balancing task performance against safety risk. Although belief-space planning provides a principled solution, maintaining and planning over beliefs can be computationally costly and sensitive to model specification in practical domains. We propose a lightweight risk-gated reinforcement learning approximation for risk-sensitive control under partial observability. The method constructs a compact finite-history proxy state and learns an action-conditioned predictor of near-term safety violation. This predicted candidate-action risk is used in two complementary ways: as a risk penalty during value learning, and as a decision-time gate that interpolates between optimistic and conservative ensemble value estimates. As a result, low-risk actions are evaluated closer to reward-seeking estimates, while high-risk actions are evaluated more conservatively. We evaluate the approach in two safety-critical partially observable domains: automated glucose regulation and safety-constrained navigation. Across adult and adolescent glucose-control cohorts, the method improves overall glycemic tradeoffs and substantially reduces runtime relative to a belief-space planning baseline. On Safety-Gym navigation benchmarks, it achieves a more favorable reward-cost balance than unconstrained RL and several standard safe-RL baselines. These results suggest that action-conditioned near-term risk can provide an effective local signal for approximate risk-sensitive POMDP control when full belief-space planning is impractical.
Abstract:Histopathology whole-slide images (WSIs) are routinely acquired in clinical practice and contain rich tissue morphology but lack direct molecular architecture and functional programs defining pathological states, whereas RNA sequencing (RNA-seq) provides genome-wide transcriptional profiles at substantial cost, thereby motivating WSI-based genome-wide transcriptomic prediction. Existing approaches for predicting gene expression from WSIs predominantly rely on deterministic regression with one-to-one mapping, limiting their ability to capture biological heterogeneity and predictive uncertainty. We propose RNA-FM, a flow-matching generative framework for genome-wide bulk RNA-seq prediction from WSIs. RNA-FM formulates transcriptomic prediction as a continuous-time conditional transport problem, learning a velocity field that maps a simple prior to the target gene expression distribution conditioned on morphologies. By integrating pathway-level structure, RNA-FM enables scalable and biologically interpretable genome-wide gene expression imputation. Extensive experiments demonstrate that RNA-FM consistently outperforms state-of-the-art approaches while maintaining biological meaningfulness. Code is available at https://github.com/YXSong000/RNA-FM.
Abstract:Watermark radioactivity testing type of methods can detect whether a model was trained on watermarked documents, and have become key tools for protecting data ownership in the fine-tuning of large language models (LLMs). Existing works have proved their effectiveness in centralized LLM fine-tuning. However, this type of method faces several challenges and remains underexplored in federated learning (FL), a widely-applied paradigm for fine-tuning LLMs collaboratively on private data across different users. FL mainly ensures privacy through secure aggregation (SA), which allows the server to aggregate updates while keeping clients' updates private. This mechanism preserves privacy but makes it difficult to identify which client trained on watermarked documents. In this work, we propose FedAttr, a new client-level attribution protocol for FL. FedAttr identifies which clients trained on watermarked data via a paired-subset-difference mechanism, while preserving the privacy guarantees of SA and FL performance. FedAttr proceeds in three steps: (i) estimate each client's update by differencing two SA queries, (ii) score the estimate with the watermark detector via differential scoring, and (iii) combine scores across rounds via Stouffer method. We theoretically show that FedAttr produces an unbiased estimator of each client's update with bounded mutual information leakage (i.e., $O(d^*/N)$ per-round update). Moreover, FedAttr empirically achieves 100% TPR and 0% FPR, outperforming all baselines by at least 44.4% in TPR or 19.1% in FPR, with only 6.3% overhead relative to FL training time. Ablation studies confirm that FedAttr is robust to protocol parameters and configurations.
Abstract:The rapid advancement of AIGC-based video generation has underscored the critical need for comprehensive evaluation frameworks that go beyond traditional generation quality metrics to encompass aesthetic appeal. However, existing benchmarks remain largely focused on technical fidelity, leaving a significant gap in holistic assessment-particularly with respect to perceptual and artistic qualities. To address this limitation, we introduce VGA-Bench, a unified benchmark for joint evaluation of video generation quality and aesthetic quality. VGA-Bench is built upon a principled three-tier taxonomy: Aesthetic Quality, Aesthetic Tagging, and Generation Quality, each decomposed into multiple fine-grained sub-dimensions to enable systematic assessment. Guided by this taxonomy, we design 1,016 diverse prompts and generate a large-scale dataset of over 60,000 videos using 12 video generation models, ensuring broad coverage across content, style, and artifacts. To enable scalable and automated evaluation, we annotate a subset of the dataset via human labeling and develop three dedicated multi-task neural assessors: VAQA-Net for aesthetic quality prediction, VTag-Net for automatic aesthetic tagging, and VGQA-Net for generation and basic quality attributes. Extensive experiments demonstrate that our models achieve reliable alignment with human judgments, offering both accuracy and efficiency. We release VGA-Bench as a public benchmark to foster research in AIGC evaluation, with applications in content moderation, model debugging, and generative model optimization.
Abstract:Fine-tuning Large Language Models (LLMs) typically involves either full fine-tuning, which updates all model parameters, or Parameter-Efficient Fine-Tuning (PEFT), which adjusts a small subset of parameters. However, both approaches have inherent limitations: full fine-tuning is computationally expensive, while PEFT often struggles to learn new knowledge and exhibits suboptimal performance. To overcome these issues, we propose a novel hybrid fine-tuning approach that jointly updates both LLMs and PEFT modules using a combination of zeroth-order and first-order optimization methods. To analyze our new algorithm, we develop a theoretical framework centered on the concept of hybrid smoothness condition, which accounts for the heterogeneous nature of the optimization landscape in joint LLM and PEFT training. We derive a rigorous convergence analysis for the convergence of reshuffling-type SGD algorithm under multiple learning rates and demonstrate its effectiveness through extensive empirical studies across various downstream tasks and model architectures. On the practical side, our results demonstrate consistent performance improvement, making the approach a viable solution for large-scale language model fine-tuning.
Abstract:Recent advances in Large Language Models (LLMs) and Text-to-Image (T2I) models have led to the emergence of Unified Multimodal Models (UMMs), where multimodal understanding and image generation are tightly integrated within a shared architecture. Prior studies suggest that such reciprocity enhances cross-functionality performance through shared representations and joint optimization. However, the safety implications of this tight coupling remain largely unexplored, as existing safety research predominantly analyzes understanding and generation functionalities in isolation. In this work, we investigate whether cross-functionality reciprocity itself constitutes a structural source of vulnerability in UMMs. We propose RICE: Reciprocal Interaction-based Cross-functionality Exploitation, a novel attack paradigm that explicitly exploits bidirectional interactions between understanding and generation. Using this framework, we systematically evaluate Generation-to-Understanding (G-U) and Understanding-to-Generation (U-G) attack pathways, demonstrating that unsafe intermediate signals can propagate across modalities and amplify safety risks. Extensive experiments show high Attack Success Rates (ASR) in both directions, revealing previously overlooked safety weaknesses inherent to UMMs.
Abstract:Accurate characterization of carotid plaques is critical for stroke prevention in patients with carotid stenosis. We analyze 500 plaques from CREST-2, a multi-center clinical trial, to identify radiomics-based markers from B-mode ultrasound images linked with high-risk. We propose a new kernel-based additive model, combining coherence loss with group-sparse regularization for nonlinear classification. Group-wise additive effects of each feature group are visualized using partial dependence plots. Results indicate our method accurately and interpretably assesses plaques, revealing a strong association between plaque texture and clinical risk.
Abstract:Large language models now produce text indistinguishable from human writing, which increases the need for reliable provenance tracing. Multi-bit watermarking can embed identifiers into generated text, but existing methods struggle to keep both text quality and watermark strength while carrying long messages. We propose MC$^2$Mark, a distortion-free multi-bit watermarking framework designed for reliable embedding and decoding of long messages. Our key technical idea is Multi-Channel Colored Reweighting, which encodes bits through structured token reweighting while keeping the token distribution unbiased, together with Multi-Layer Sequential Reweighting to strengthen the watermark signal and an evidence-accumulation detector for message recovery. Experiments show that MC$^2$Mark improves detectability and robustness over prior multi-bit watermarking methods while preserving generation quality, achieving near-perfect accuracy for short messages and exceeding the second-best method by nearly 30% for long messages.